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Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes

Sickness evokes various neural responses, one of which is activation of the hypothalamo–pituitary–adrenal (HPA) axis. This response can be induced experimentally by injection of bacterial lipopolysaccharide (LPS) or inflammatory cytokines such as IL-1. Although prostaglandins (PGs) long have been im...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Matsuoka, Yoko, Furuyashiki, Tomoyuki, Bito, Haruhiko, Ushikubi, Fumitaka, Tanaka, Yasuhiro, Kobayashi, Takuya, Muro, Seiji, Satoh, Noriko, Kayahara, Tetsuro, Higashi, Mikito, Mizoguchi, Akira, Shichi, Hitoshi, Fukuda, Yoshihiro, Nakao, Kazuwa, Narumiya, Shuh
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2003
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC153060/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12642666/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0633341100
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