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Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations
DNA polymerases replicate DNA by adding nucleotides to a growing primer strand while avoiding frameshift and point mutations. Here we present a series of up to six successive replication events that were obtained by extension of a primed template directly in a crystal of the thermostable Bacillus DN...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC153019/ https://ncbi.nlm.nih.gov/pubmed/12649320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0630532100 |
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