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Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint

All eukaryotes respond to DNA damage by modulation of diverse cellular processes to preserve genomic integrity and ensure survival. Here we identify mammalian Tousled like kinases (Tlks) as a novel target of the DNA damage checkpoint. During S-phase progression, when Tlks are maximally active, gener...

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Udgivet i:EMBO J
Principais autores: Groth, Anja, Lukas, Jiri, Nigg, Erich A., Silljé, Herman H.W., Wernstedt, Christer, Bartek, Jiri, Hansen, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2003
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152895/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12660173/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg151
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