Dihydropyrimidine amidohydrolases and dihydroorotases share the same origin and several enzymatic properties

Slime mold, plant and insect dihydropyrimidine amidohydrolases (DHPases, EC 3.5.2.2), which catalyze the second step of pyrimidine and several anti-cancer drug degradations, were cloned and shown to functionally replace a defective DHPase enzyme in the yeast Saccharomyces kluyveri. The yeast and sli...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Gojkovic, Zoran, Rislund, Lise, Andersen, Birgit, Sandrini, Michael P. B., Cook, Paul F., Schnackerz, Klaus D., Piškur, Jure
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2003
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152861/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12626710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg258
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