Dihydropyrimidine amidohydrolases and dihydroorotases share the same origin and several enzymatic properties

Slime mold, plant and insect dihydropyrimidine amidohydrolases (DHPases, EC 3.5.2.2), which catalyze the second step of pyrimidine and several anti-cancer drug degradations, were cloned and shown to functionally replace a defective DHPase enzyme in the yeast Saccharomyces kluyveri. The yeast and sli...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Gojkovic, Zoran, Rislund, Lise, Andersen, Birgit, Sandrini, Michael P. B., Cook, Paul F., Schnackerz, Klaus D., Piškur, Jure
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2003
Soggetti:	Articles
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152861/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12626710/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg258
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