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Inhibition of HCV NS3 protease by RNA aptamers in cells

Non-structural protein 3 (NS3) of hepatitis C virus (HCV) has two distinct activities, protease and helicase, which are essential for HCV proliferation. In previous work, we obtained RNA aptamers (G9-I, II and III) which specifically bound the NS3 protease domain (ΔNS3), efficiently inhibiting prote...

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Bibliografiske detaljer
Main Authors: Nishikawa, Fumiko, Kakiuchi, Nobuko, Funaji, Kohei, Fukuda, Kotaro, Sekiya, Satoru, Nishikawa, Satoshi
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC152807/
https://ncbi.nlm.nih.gov/pubmed/12655010
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