Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease

NS4A is a non-structural multi-tasking small peptide that is essential for HCV maturation and replication. The central odd-numbered hydrophobic residues of NS4A (Val-23‘ to Leu-31‘) are essential for activating NS3 upon NS3/4A protease complex formation. This study aims to design new specific allost...

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Foilsithe in:J Adv Res
Main Authors: El-Araby, Moustafa E., Omar, Abdelsattar M., Soror, Sameh H., Arold, Stefan T., Khayat, Maan T., Asfour, Hani Z., Bamane, Faida, Elfaky, Mahmoud A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7195562/
https://ncbi.nlm.nih.gov/pubmed/32373358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jare.2020.01.003
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