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Synthetic bulky NS4A peptide variants bind to and inhibit HCV NS3 protease
NS4A is a non-structural multi-tasking small peptide that is essential for HCV maturation and replication. The central odd-numbered hydrophobic residues of NS4A (Val-23‘ to Leu-31‘) are essential for activating NS3 upon NS3/4A protease complex formation. This study aims to design new specific allost...
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| Pubblicato in: | J Adv Res |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7195562/ https://ncbi.nlm.nih.gov/pubmed/32373358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jare.2020.01.003 |
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