The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis

S100A8 and S100A9, two Ca(2+)-binding proteins of the S100 family, are secreted as a heterodimeric complex (S100A8/A9) from neutrophils and monocytes/macrophages. Serum and synovial fluid levels of S100A8, S100A9, and S100A8/A9 were all higher in patients with rheumatoid arthritis (RA) than in patie...

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Detalhes bibliográficos
Main Authors: Sunahori, Katsue, Yamamura, Masahiro, Yamana, Jiro, Takasugi, Kouji, Kawashima, Masanori, Yamamoto, Hiroshi, Chazin, Walter J, Nakatani, Yuichi, Yui, Satoru, Makino, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1526633/
https://ncbi.nlm.nih.gov/pubmed/16613612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1939
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