Down-regulation of p38 mitogen-activated protein kinase activation and proinflammatory cytokine production by mitogen-activated protein kinase inhibitors in inflammatory bowel disease

Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBD) characterized by chronic relapsing mucosal inflammation. Tumour necrosis factor (TNF)-α, a known agonist of the mitogen-activated protein kinase (MAPK) pathway, is a key cytokine in this process. We aimed first to dete...

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Detalhes bibliográficos
Main Authors: Docena, G, Rovedatti, L, Kruidenier, L, Fanning, Á, Leakey, N A B, Knowles, C H, Lee, K, Shanahan, F, Nally, K, McLean, P G, Di Sabatino, A, MacDonald, T T
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Translational Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2990936/
https://ncbi.nlm.nih.gov/pubmed/20731675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2010.04203.x
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