Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4(+ )T cells from patients with rheumatoid arthritis

IL-10 has been shown to block the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway. We found that peripheral blood CD4(+ )T cells from patients with active rheumatoid arthritis (RA) were able to produce greater amounts of interferon gamma after CD3 and CD28 costimul...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Yamana, Jiro, Yamamura, Masahiro, Okamoto, Akira, Aita, Tetsushi, Iwahashi, Mitsuhiro, Sunahori, Katsue, Makino, Hirofumi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2004
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064873/
https://ncbi.nlm.nih.gov/pubmed/15535835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1445
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky