Resistance to IL-10 inhibition of interferon gamma production and expression of suppressor of cytokine signaling 1 in CD4(+ )T cells from patients with rheumatoid arthritis

IL-10 has been shown to block the antigen-specific T-cell cytokine response by inhibiting the CD28 signaling pathway. We found that peripheral blood CD4(+ )T cells from patients with active rheumatoid arthritis (RA) were able to produce greater amounts of interferon gamma after CD3 and CD28 costimul...

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Main Authors: Yamana, Jiro, Yamamura, Masahiro, Okamoto, Akira, Aita, Tetsushi, Iwahashi, Mitsuhiro, Sunahori, Katsue, Makino, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2004
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064873/
https://ncbi.nlm.nih.gov/pubmed/15535835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1445
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