The Tumor Suppressor p53 and Histone Deacetylase 1 Are Antagonistic Regulators of the Cyclin-Dependent Kinase Inhibitor p21/WAF1/CIP1 Gene

The cyclin-dependent kinase inhibitor p21/WAF1/CIP1 is an important regulator of cell cycle progression, senescence, and differentiation. Genotoxic stress leads to activation of the tumor suppressor p53 and subsequently to induction of p21 expression. Here we show that the tumor suppressor p53 coope...

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Podrobná bibliografie

Vydáno v:	Mol Cell Biol
Hlavní autoři:	Lagger, Gerda, Doetzlhofer, Angelika, Schuettengruber, Bernd, Haidweger, Eva, Simboeck, Elisabeth, Tischler, Julia, Chiocca, Susanna, Suske, Guntram, Rotheneder, Hans, Wintersberger, Erhard, Seiser, Christian
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2003
Témata:	Transcriptional Regulation
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152549/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12665570/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.8.2669-2679.2003
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