The Tumor Suppressor p53 and Histone Deacetylase 1 Are Antagonistic Regulators of the Cyclin-Dependent Kinase Inhibitor p21/WAF1/CIP1 Gene

The cyclin-dependent kinase inhibitor p21/WAF1/CIP1 is an important regulator of cell cycle progression, senescence, and differentiation. Genotoxic stress leads to activation of the tumor suppressor p53 and subsequently to induction of p21 expression. Here we show that the tumor suppressor p53 coope...

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Autors principals: Lagger, Gerda, Doetzlhofer, Angelika, Schuettengruber, Bernd, Haidweger, Eva, Simboeck, Elisabeth, Tischler, Julia, Chiocca, Susanna, Suske, Guntram, Rotheneder, Hans, Wintersberger, Erhard, Seiser, Christian
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
Matèries:
Transcriptional Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC152549/
https://ncbi.nlm.nih.gov/pubmed/12665570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.8.2669-2679.2003
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