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The P4 metal binding site in RNase P RNA affects active site metal affinity through substrate positioning
Although helix P4 in the catalytic domain of the RNase P ribozyme is known to coordinate magnesium ions important for activity, distinguishing between direct and indirect roles in catalysis has been difficult. Here, we provide evidence for an indirect role in catalysis by showing that while the univ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1524898/ https://ncbi.nlm.nih.gov/pubmed/16822954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.158606 |
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