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Pharmacokinetics and Metabolism of [(14)C]Ribavirin in Rats and Cynomolgus Monkeys

Absorption, pharmacokinetics, distribution, metabolism, and excretion of [(14)C]ribavirin were studied in rats (30 mg/kg of body weight) and cynomolgus monkeys (10 mg/kg) after intravenous (i.v.) and oral administration. The oral absorption and bioavailability were 83 and 59%, respectively, in rats...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Lin, Chin-Chung, Yeh, Li-Tain, Luu, Trong, Lourenco, David, Lau, Johnson Y. N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2003
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC152481/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12654676/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.4.1395-1398.2003
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