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Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

RNA interference (RNAi) was first recognized in Caenorhabditis elegans as a biological response to exogenous double-stranded RNA (dsRNA), which induces sequence-specific gene silencing. RNAi represents a conserved regulatory motif, which is present in a wide range of eukaryotic organisms. Recently,...

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Main Authors: Paddison, Patrick J., Caudy, Amy A., Bernstein, Emily, Hannon, Gregory J., Conklin, Douglas S.
פורמט: Artigo
שפה:Inglês
יצא לאור: Cold Spring Harbor Laboratory Press 2002
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC152352/
https://ncbi.nlm.nih.gov/pubmed/11959843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.981002
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