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Inhibition of T cell activation and autoimmune diabetes using a B cell surface–linked CTLA-4 agonist
CTL-associated antigen 4 (CTLA-4) engagement negatively regulates T cell activation and function and promotes immune tolerance. However, it has been difficult to explore the biology of selective engagement of CTLA-4 in vivo because CTLA-4 shares its ligands, B7-1 and B7-2, with CD28. To address this...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1523399/ https://ncbi.nlm.nih.gov/pubmed/16886063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27856 |
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