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IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells

To protect the organism against autoimmunity, self-reactive effector/memory T cells (T(E/M)) are controlled by cell-intrinsic and -extrinsic regulatory mechanisms. However, how some T(E/M) cells escape regulation and cause autoimmune disease is currently not understood. Here we show that blocking IL...

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Detalhes bibliográficos
Main Authors: Penaranda, Cristina, Kuswanto, Wilson, Hofmann, Jerry, Kenefeck, Rupert, Narendran, Parth, Walker, Lucy S. K., Bluestone, Jeffrey A., Abbas, Abul K., Dooms, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411948/
https://ncbi.nlm.nih.gov/pubmed/22733744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203692109
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