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Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

The excessive generation and accumulation of 40- and 42-aa β-amyloid peptides (Aβ(40)/Aβ(42)) in selectively vulnerable brain regions is a major neuropathological feature of Alzheimer’s disease. Aβ, derived by proteolytic cleavage from the β-amyloid precursor protein (βAPP), is normally secreted. Ho...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Greenfield, Jeffrey P., Tsai, Julia, Gouras, Gunnar K., Hai, Bing, Thinakaran, Gopal, Checler, Frederic, Sisodia, Sangram S., Greengard, Paul, Xu, Huaxi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15207/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9892704/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.2.742
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