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Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
The excessive generation and accumulation of 40- and 42-aa β-amyloid peptides (Aβ(40)/Aβ(42)) in selectively vulnerable brain regions is a major neuropathological feature of Alzheimer’s disease. Aβ, derived by proteolytic cleavage from the β-amyloid precursor protein (βAPP), is normally secreted. Ho...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC15207/ https://ncbi.nlm.nih.gov/pubmed/9892704 |
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