Interleukin-18 Impairs the Pulmonary Host Response to Pseudomonas aeruginosa

Interleukin-18 (IL-18) is a potent cytokine with many different proinflammatory activities. To study the role of IL-18 in the pathogenesis of Pseudomonas pneumonia, IL-18-deficient (IL-18(−/−)) and wild-type mice were intranasally inoculated with Pseudomonas aeruginosa. IL-18 deficiency was associat...

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Detalhes bibliográficos
Main Authors: Schultz, Marc J., Knapp, Sylvia, Florquin, Sandrine, Pater, Jennie, Takeda, Kiyoshi, Akira, Shizuo, van der Poll, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC152024/
https://ncbi.nlm.nih.gov/pubmed/12654774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.4.1630-1634.2003
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