CXCR4 utilization is sufficient to trigger CD4+ T cell depletion in HIV-1-infected human lymphoid tissue

The human chemokine receptors CCR5 and CXCR4 have emerged as the predominant cofactors, along with CD4, for cellular entry of HIV-1 in vivo whereas the contribution of other chemokine receptors to HIV disease has not been yet determined. CCR5-specific (R5) viruses predominate during primary HIV-1 in...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Penn, Michael L., Grivel, Jean-Charles, Schramm, Birgit, Goldsmith, Mark A., Margolis, Leonid
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9892690/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.2.663
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