Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes

To elucidate the function of PPARγ in leptin-deficient mouse (ob/ob) liver, a PPARγ liver-null mouse on an ob/ob background, ob/ob-PPARγ(fl/fl)AlbCre(+), was produced using a floxed PPARγ allele, PPARγ(fl/fl), and Cre recombinase under control of the albumin promoter (AlbCre). The liver of ob/ob-PPA...

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Hlavní autoři: Matsusue, Kimihiko, Haluzik, Martin, Lambert, Gilles, Yim, Sun-Hee, Gavrilova, Oksana, Ward, Jerrold M., Brewer, Bryan, Reitman, Marc L., Gonzalez, Frank J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2003
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC151902/
https://ncbi.nlm.nih.gov/pubmed/12618528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317223
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