Hepatic steatosis in leptin-deficient mice is promoted by the PPARγ target gene, fat-specific protein 27

PPARγ is induced in leptin-deficient mouse (ob/ob) liver and is critical for the development of hepatic steatosis. The present study shows that fsp27 in ob/ob liver is a direct target gene of PPARγ and can elevate hepatic triglyceride levels. Fsp27 belongs to the cide family, composed of cide a, cid...

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Bibliographic Details
Main Authors: Matsusue, Kimihiko, Kusakabe, Takashi, Noguchi, Takahiro, Takiguchi, Shouichi, Suzuki, Toshimitsu, Yamano, Shigeru, Gonzalez, Frank J.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2587176/
https://ncbi.nlm.nih.gov/pubmed/18396136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.03.003
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