Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

Preeclampsia, a syndrome affecting 5% of pregnancies, causes substantial maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia remains largely unknown. It has been hypothesized that placental ischemia is an early event, leading to placental production of a soluble factor or...

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Autors principals: Maynard, Sharon E., Min, Jiang-Yong, Merchan, Jaime, Lim, Kee-Hak, Li, Jianyi, Mondal, Susanta, Libermann, Towia A., Morgan, James P., Sellke, Frank W., Stillman, Isaac E., Epstein, Franklin H., Sukhatme, Vikas P., Karumanchi, S. Ananth
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2003
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC151901/
https://ncbi.nlm.nih.gov/pubmed/12618519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317189
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