Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

Preeclampsia, a syndrome affecting 5% of pregnancies, causes substantial maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia remains largely unknown. It has been hypothesized that placental ischemia is an early event, leading to placental production of a soluble factor or...

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Main Authors: Maynard, Sharon E., Min, Jiang-Yong, Merchan, Jaime, Lim, Kee-Hak, Li, Jianyi, Mondal, Susanta, Libermann, Towia A., Morgan, James P., Sellke, Frank W., Stillman, Isaac E., Epstein, Franklin H., Sukhatme, Vikas P., Karumanchi, S. Ananth
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC151901/
https://ncbi.nlm.nih.gov/pubmed/12618519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317189
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