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Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

Preeclampsia, a syndrome affecting 5% of pregnancies, causes substantial maternal and fetal morbidity and mortality. The pathophysiology of preeclampsia remains largely unknown. It has been hypothesized that placental ischemia is an early event, leading to placental production of a soluble factor or...

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Detalhes bibliográficos
Main Authors: Maynard, Sharon E., Min, Jiang-Yong, Merchan, Jaime, Lim, Kee-Hak, Li, Jianyi, Mondal, Susanta, Libermann, Towia A., Morgan, James P., Sellke, Frank W., Stillman, Isaac E., Epstein, Franklin H., Sukhatme, Vikas P., Karumanchi, S. Ananth
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151901/
https://ncbi.nlm.nih.gov/pubmed/12618519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200317189
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