Essential role for proteinase-activated receptor-2 in arthritis

Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation. Using an adjuvant monoarthritis model of chronic inflammation, joint swelling was substantially inhibited in PAR-2...

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Detalhes bibliográficos
Main Authors: Ferrell, William R., Lockhart, John C., Kelso, Elizabeth B., Dunning, Lynette, Plevin, Robin, Meek, Stephen E., Smith, Andrew J.H., Hunter, Gary D., McLean, John S., McGarry, Frances, Ramage, Robert, Jiang, Lu, Kanke, Toru, Kawagoe, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151840/
https://ncbi.nlm.nih.gov/pubmed/12511586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316913
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