Essential role for proteinase-activated receptor-2 in arthritis

Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation. Using an adjuvant monoarthritis model of chronic inflammation, joint swelling was substantially inhibited in PAR-2...

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Bibliografische gegevens
Hoofdauteurs: Ferrell, William R., Lockhart, John C., Kelso, Elizabeth B., Dunning, Lynette, Plevin, Robin, Meek, Stephen E., Smith, Andrew J.H., Hunter, Gary D., McLean, John S., McGarry, Frances, Ramage, Robert, Jiang, Lu, Kanke, Toru, Kawagoe, Junichi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2003
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC151840/
https://ncbi.nlm.nih.gov/pubmed/12511586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316913
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