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Expression of constitutively active 4EBP-1 enhances p27(Kip1 )expression and inhibits proliferation of MCF7 breast cancer cells
BACKGROUND: Eukaryotic initiation factor 4E (eIF4E) is essential for cap-dependent initiation of translation. Cell proliferation is associated with increased activity of eIF4E and elevated expression of eIF4E leads to tumorigenic transformation. Many tumors express very high levels of eIF4E and this...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2003
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151675/ https://ncbi.nlm.nih.gov/pubmed/12633504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-3-2 |
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