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Expression of constitutively active 4EBP-1 enhances p27(Kip1 )expression and inhibits proliferation of MCF7 breast cancer cells

BACKGROUND: Eukaryotic initiation factor 4E (eIF4E) is essential for cap-dependent initiation of translation. Cell proliferation is associated with increased activity of eIF4E and elevated expression of eIF4E leads to tumorigenic transformation. Many tumors express very high levels of eIF4E and this...

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書誌詳細
主要な著者: Jiang, Hong, Coleman, Jennifer, Miskimins, Robin, Miskimins, W Keith
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC151675/
https://ncbi.nlm.nih.gov/pubmed/12633504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-3-2
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