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Expression of constitutively active 4EBP-1 enhances p27(Kip1 )expression and inhibits proliferation of MCF7 breast cancer cells
BACKGROUND: Eukaryotic initiation factor 4E (eIF4E) is essential for cap-dependent initiation of translation. Cell proliferation is associated with increased activity of eIF4E and elevated expression of eIF4E leads to tumorigenic transformation. Many tumors express very high levels of eIF4E and this...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BioMed Central
2003
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151675/ https://ncbi.nlm.nih.gov/pubmed/12633504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-3-2 |
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