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Structure and activity of the internal ribosome entry site within the human p27(Kip1) 5′-untranslated region

The cyclin dependent kinase inhibitor p27(Kip1) is a key cell cycle regulatory protein that is often downregulated in cancer cells. The cellular levels of p27(Kip1) are regulated, in part, through translational control mechanisms. The 5′-UTR of the p27(Kip1) mRNA is known to harbor an IRES that may...

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Bibliografiske detaljer
Udgivet i:RNA Biol
Main Authors: Coleman, Jennifer, Miskimins, W. Keith
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067003/
https://ncbi.nlm.nih.gov/pubmed/19106631
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