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Structure and activity of the internal ribosome entry site within the human p27(Kip1) 5′-untranslated region

The cyclin dependent kinase inhibitor p27(Kip1) is a key cell cycle regulatory protein that is often downregulated in cancer cells. The cellular levels of p27(Kip1) are regulated, in part, through translational control mechanisms. The 5′-UTR of the p27(Kip1) mRNA is known to harbor an IRES that may...

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書目詳細資料
發表在:RNA Biol
Main Authors: Coleman, Jennifer, Miskimins, W. Keith
格式: Artigo
語言:Inglês
出版: 2009
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6067003/
https://ncbi.nlm.nih.gov/pubmed/19106631
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