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Expression of constitutively active 4EBP-1 enhances p27(Kip1 )expression and inhibits proliferation of MCF7 breast cancer cells

BACKGROUND: Eukaryotic initiation factor 4E (eIF4E) is essential for cap-dependent initiation of translation. Cell proliferation is associated with increased activity of eIF4E and elevated expression of eIF4E leads to tumorigenic transformation. Many tumors express very high levels of eIF4E and this...

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Detalhes bibliográficos
Main Authors: Jiang, Hong, Coleman, Jennifer, Miskimins, Robin, Miskimins, W Keith
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151675/
https://ncbi.nlm.nih.gov/pubmed/12633504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-3-2
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