A G(sα) mutant designed to inhibit receptor signaling through G(s)

Hormonal signals activate trimeric G proteins by substituting GTP for GDP bound to the G protein α subunit (Gα), thereby generating two potential signaling molecules, Gα–GTP and free Gβγ. The usefulness of dominant negative mutations for investigating Ras and other monomeric G proteins inspired us t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Iiri, Taroh, Bell, Sean M., Baranski, Thomas J., Fujita, Toshiro, Bourne, Henry R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15165/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9892662/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.2.499
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