A G(sα) mutant designed to inhibit receptor signaling through G(s)

Hormonal signals activate trimeric G proteins by substituting GTP for GDP bound to the G protein α subunit (Gα), thereby generating two potential signaling molecules, Gα–GTP and free Gβγ. The usefulness of dominant negative mutations for investigating Ras and other monomeric G proteins inspired us t...

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Autores principales: Iiri, Taroh, Bell, Sean M., Baranski, Thomas J., Fujita, Toshiro, Bourne, Henry R.
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 1999
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC15165/
https://ncbi.nlm.nih.gov/pubmed/9892662
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