Extensive Loss of Heterozygosity Is Suppressed during Homologous Repair of Chromosomal Breaks

Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several megabases to encompass multiple genetic loci or even whole chromosome arms. Based on marker and karyotype analysis of tumor samples, a significant fraction of LOH events appears to arise from mitotic reco...

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Vydáno v:	Mol Cell Biol
Hlavní autoři:	Stark, Jeremy M., Jasin, Maria
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis 2003
Témata:	DNA Dynamics and Chromosome Structure
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151548/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12509470/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.2.733-743.2003
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