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Extensive Loss of Heterozygosity Is Suppressed during Homologous Repair of Chromosomal Breaks
Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several megabases to encompass multiple genetic loci or even whole chromosome arms. Based on marker and karyotype analysis of tumor samples, a significant fraction of LOH events appears to arise from mitotic reco...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151548/ https://ncbi.nlm.nih.gov/pubmed/12509470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.2.733-743.2003 |
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