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Extensive Loss of Heterozygosity Is Suppressed during Homologous Repair of Chromosomal Breaks

Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several megabases to encompass multiple genetic loci or even whole chromosome arms. Based on marker and karyotype analysis of tumor samples, a significant fraction of LOH events appears to arise from mitotic reco...

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Библиографические подробности
Главные авторы: Stark, Jeremy M., Jasin, Maria
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2003
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC151548/
https://ncbi.nlm.nih.gov/pubmed/12509470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.2.733-743.2003
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