mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation
The function of the p53 tumor suppressor protein must be highly regulated because p53 can cause cell death and prevent tumorigenesis. In cultured cells, the p90(MDM2) protein blocks the transcriptional activation domain of p53 and also stimulates the degradation of p53. Here we provide the first con...
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| Опубліковано в:: | Mol Cell Biol |
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| Автори: | , , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Taylor & Francis
2003
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151546/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12509446/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.2.462-473.2003 |
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