mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation

The function of the p53 tumor suppressor protein must be highly regulated because p53 can cause cell death and prevent tumorigenesis. In cultured cells, the p90(MDM2) protein blocks the transcriptional activation domain of p53 and also stimulates the degradation of p53. Here we provide the first con...

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Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Mendrysa, Susan M., McElwee, Matthew K., Michalowski, Jennifer, O'Leary, Kathleen A., Young, Karen M., Perry, Mary Ellen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 2003
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151546/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12509446/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.2.462-473.2003
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