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Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease

We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human α-synuclein in the substantia nigra of adult marmosets. The α-synuclein protein was expressed in 90–95% of all nigral dopamine neurons and distributed by anterograde transport throughout their axonal...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kirik, Deniz, Annett, Lucy E., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Björklund, Anders
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 2003
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC151435/
https://ncbi.nlm.nih.gov/pubmed/12601150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0536383100
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