Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells

Up-regulation of cyclooxygenase-2 (COX-2) and overproduction of prostaglandins have been implicated in the initiation and/or progression of colon cancer. However, it is uncertain in which cells and how COX-2 is induced initially in the tumor microenvironment. We found that a conditioned medium of th...

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Main Authors: Inaba, Takaaki, Sano, Hajime, Kawahito, Yutaka, Hla, Timothy, Akita, Kaoru, Toda, Munetoyo, Yamashina, Ikuo, Inoue, Mizue, Nakada, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC151410/
https://ncbi.nlm.nih.gov/pubmed/12598658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0435410100
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