MUC1 Protein Induces Urokinase-type Plasminogen Activator (uPA) by Forming a Complex with NF-κB p65 Transcription Factor and Binding to the uPA Promoter, Leading to Enhanced Invasiveness of Cancer Cells

Mucin 1 (MUC1) is overexpressed in various human malignant tumors and its expression is correlated with a poor prognosis. MUC1 engages in signal transduction by interacting with receptors for growth and differentiation factors, which contributes to the growth and survival of cancer cells. However, t...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Mori, Yugo, Akita, Kaoru, Tanida, Shuhei, Ishida, Akiko, Toda, Munetoyo, Inoue, Mizue, Yashiro, Masakazu, Sawada, Tetsuji, Hirakawa, Kosei, Nakada, Hiroshi
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Glycobiology and Extracellular Matrices
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271208/
https://ncbi.nlm.nih.gov/pubmed/25371209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.586461
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