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Negative Regulation of Toll-like Receptor-4 Signaling through the Binding of Glycosylphosphatidylinositol-anchored Glycoprotein, CD14, with the Sialic Acid-binding Lectin, CD33

When monocyte-derived immature dendritic cells (imDCs) were stimulated with LPS in the presence of anti-CD33/Siglec-3 mAb, the production of IL-12 and phosphorylation of NF-κB decreased significantly. The cell surface proteins of imDCs were chemically cross-linked, and CD33-linked proteins were anal...

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Detalhes bibliográficos
Main Authors: Ishida, Akiko, Akita, Kaoru, Mori, Yugo, Tanida, Shuhei, Toda, Munetoyo, Inoue, Mizue, Nakada, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155695/
https://ncbi.nlm.nih.gov/pubmed/25059667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523480
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