Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

The highly homologous Rnf2 (Ring1b) and Ring1 (Ring1a) proteins were identified as in vivo interactors of the Polycomb Group (PcG) protein Bmi1. Functional ablation of Rnf2 results in gastrulation arrest, in contrast to relatively mild phenotypes in most other PcG gene null mutants belonging to the...

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Bibliografiska uppgifter
Huvudupphovsmän: Voncken, Jan Willem, Roelen, Bernard A. J., Roefs, Mieke, de Vries, Stijn, Verhoeven, Els, Marino, Silvia, Deschamps, Jacqueline, van Lohuizen, Maarten
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences 2003
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC151364/
https://ncbi.nlm.nih.gov/pubmed/12589020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0434312100
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