Ubiquitin E3 Ligase Ring1b/Rnf2 of Polycomb Repressive Complex 1 Contributes to Stable Maintenance of Mouse Embryonic Stem Cells

BACKGROUND: Polycomb repressive complex 1 (PRC1) core member Ring1b/Rnf2, with ubiquitin E3 ligase activity towards histone H2A at lysine 119, is essential for early embryogenesis. To obtain more insight into the role of Ring1b in early development, we studied its function in mouse embryonic stem (E...

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Detalhes bibliográficos
Main Authors: van der Stoop, Petra, Boutsma, Erwin A., Hulsman, Danielle, Noback, Sonja, Heimerikx, Mike, Kerkhoven, Ron M., Voncken, J. Willem, Wessels, Lodewyk F. A., van Lohuizen, Maarten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375055/
https://ncbi.nlm.nih.gov/pubmed/18493325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002235
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