Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

The highly homologous Rnf2 (Ring1b) and Ring1 (Ring1a) proteins were identified as in vivo interactors of the Polycomb Group (PcG) protein Bmi1. Functional ablation of Rnf2 results in gastrulation arrest, in contrast to relatively mild phenotypes in most other PcG gene null mutants belonging to the...

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Detalhes bibliográficos
Main Authors: Voncken, Jan Willem, Roelen, Bernard A. J., Roefs, Mieke, de Vries, Stijn, Verhoeven, Els, Marino, Silvia, Deschamps, Jacqueline, van Lohuizen, Maarten
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151364/
https://ncbi.nlm.nih.gov/pubmed/12589020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0434312100
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