JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
The c-Jun NH(2)-terminal kinase (JNK) is activated when cells are exposed to environmental stress, including UV radiation. Gene disruption studies demonstrate that JNK is essential for UV-stimulated apoptosis mediated by the mitochondrial pathway by a Bax/Bak-dependent mechanism. Here, we demonstrat...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151358/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12591950/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0438011100 |
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