p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop

DDR1, discoidin domain receptor 1, belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. We showed that DDR1 is a direct p53 transcriptional target, and that DNA damage induced a p53-dependent DDR1 response assoc...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Ongusaha, Pat P., Kim, Jong-il, Fang, Li, Wong, Tai W., Yancopoulos, George D., Aaronson, Stuart A., Lee, Sam W.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2003
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151063/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12628922/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg129
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