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p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop

DDR1, discoidin domain receptor 1, belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. We showed that DDR1 is a direct p53 transcriptional target, and that DNA damage induced a p53-dependent DDR1 response assoc...

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Detalhes bibliográficos
Main Authors: Ongusaha, Pat P., Kim, Jong-il, Fang, Li, Wong, Tai W., Yancopoulos, George D., Aaronson, Stuart A., Lee, Sam W.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151063/
https://ncbi.nlm.nih.gov/pubmed/12628922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg129
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