p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop

DDR1, discoidin domain receptor 1, belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. We showed that DDR1 is a direct p53 transcriptional target, and that DNA damage induced a p53-dependent DDR1 response assoc...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Ongusaha, Pat P., Kim, Jong-il, Fang, Li, Wong, Tai W., Yancopoulos, George D., Aaronson, Stuart A., Lee, Sam W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151063/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12628922/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg129
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