Pharmacology of LR-B/081, a new highly potent, selective and orally active, nonpeptide angiotensin II AT1 receptor antagonist.

1. The pharmacological profile of LR-B/081, (methyl 2-[[4-butyl-2-methyl- 6-oxo-5-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1(6H)- pyrimidinyl]methyl]-3-thiophenecarboxylate), a novel antagonist at the angiotensin II (AII) AT1-receptor, was studied in vitro and in vivo. 2. In rab...

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Detalhes bibliográficos
Main Authors: Cirillo, R, Renzetti, A R, Cucchi, P, Guelfi, M, Salimbeni, A, Caliari, S, Castellucci, A, Evangelista, S, Subissi, A, Giachetti, A
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1510339/
https://ncbi.nlm.nih.gov/pubmed/7620700
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