Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets.

1. Islets from normal mice were used to test the acute effects of genistein, a potent tyrosine kinase inhibitor, on stimulus-secretion coupling in pancreatic beta-cells. 2. Genistein produced a concentration-dependent (10-100 microM), reversible, increase of insulin release. This effect was marginal...

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Библиографические подробности
Главные авторы: Jonas, J C, Plant, T D, Gilon, P, Detimary, P, Nenquin, M, Henquin, J C
Формат: Artigo
Язык:Inglês
Опубликовано: 1995
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1510214/
https://ncbi.nlm.nih.gov/pubmed/7773549
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