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Two sites of glucose control of insulin release with distinct dependence on the energy state in pancreatic B-cells.

The energy state of pancreatic B-cells may influence insulin release at several steps of stimulus-secretion coupling. By closing ATP-sensitive K+ channels (K(+)-ATP channels), a rise in the ATP/ADP ratio may regulate the membrane potential, and hence Ca2+ influx. It may also modulate the effectivene...

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Main Authors: Detimary, P, Gilon, P, Nenquin, M, Henquin, J C
Format: Artigo
Jezik:Inglês
Izdano: 1994
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1137855/
https://ncbi.nlm.nih.gov/pubmed/8110181
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