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Anabolic effects of a G protein–coupled receptor kinase inhibitor expressed in osteoblasts
G protein–coupled receptors (GPCRs) play a key role in regulating bone remodeling. Whether GPCRs exert anabolic or catabolic osseous effects may be determined by the rate of receptor desensitization in osteoblasts. Receptor desensitization is largely mediated by direct phosphorylation of GPCR protei...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC150976/ https://ncbi.nlm.nih.gov/pubmed/12021252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14663 |
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