Pdx1 restores β cell function in Irs2 knockout mice

The homeodomain transcription factor Pdx1 is required for pancreas development, including the differentiation and function of β cells. Mutations in Pdx1 or upstream hepatocyte nuclear factors cause autosomal forms of early-onset diabetes (maturity-onset diabetes of the young [MODY]). In mice, the Ir...

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Autori principali: Kushner, Jake A., Ye, Jing, Schubert, Markus, Burks, Deborah J., Dow, Matthew A., Flint, Carrie L., Dutta, Sanjoy, Wright, Christopher V.E., Montminy, Marc R., White, Morris F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC150960/
https://ncbi.nlm.nih.gov/pubmed/11994408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI14439
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